3SND

Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (cocrystallization)

Summary for 3SND

• Entry DOI: 10.2210/pdb3snd/pdb
• Related: 2h2z 3SN8 3SNA 3SNB 3SNC 3SNE
• Related PRD ID: PRD_000772
• Descriptor: 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (4 entities in total)
• Functional Keywords: 3c-like proteinase, protease, ac-estlq-h, active site, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: SARS coronavirus (SARS-CoV)
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• Total number of polymer chains: 4
• Total formula weight: 69048.75

Authors

Zhu, L.,Hilgenfeld, R. (deposition date: 2011-06-29, release date: 2011-09-07, Last modification date: 2012-12-12)

• Primary citation: Zhu, L.,George, S.,Schmidt, M.F.,Al-Gharabli, S.I.,Rademann, J.,Hilgenfeld, R.; Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.; Antiviral Res., 92:204-212, 2011; PubMed: 21854807; DOI: 10.1016/j.antiviral.2011.08.001

Experimental method

X-RAY DIFFRACTION (1.89 Å)