3SNE
Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (Soaking)
Summary for 3SNE
Entry DOI | 10.2210/pdb3sne/pdb |
Related | 2H2Z 3SN8 3SNA 3SNB 3SNC 3SND |
Related PRD ID | PRD_000772 |
Descriptor | 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | sars coronavirus main protease, 3c-like proteinase, protease, inhibitor ac-estlq-h, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 34660.53 |
Authors | Zhu, L.,Hilgenfeld, R. (deposition date: 2011-06-29, release date: 2011-09-07, Last modification date: 2012-12-12) |
Primary citation | Zhu, L.,George, S.,Schmidt, M.F.,Al-Gharabli, S.I.,Rademann, J.,Hilgenfeld, R. Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92:204-212, 2011 Cited by PubMed: 21854807DOI: 10.1016/j.antiviral.2011.08.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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