3SND

Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (cocrystallization)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MRD A 307

Chain	Residue
A	PRO108
A	GLY109
A	ILE200
A	LEU202
A	HIS246
A	HOH322
A	HOH366
A	HOH454
A	HOH534

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772

Chain	Residue	Details
A	HIS41
A	CYS145
B	HIS41
B	CYS145

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748

Chain	Residue	Details
A	GLN306
B	GLN306

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 830

Chain	Residue	Details
A	HIS41	proton acceptor, proton donor
A	GLY143	electrostatic stabiliser
A	CYS145	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 830

Chain	Residue	Details
B	HIS41	proton acceptor, proton donor
B	GLY143	electrostatic stabiliser
B	CYS145	electrostatic stabiliser

---