3RTS

Human MMP-12 catalytic domain in complex with*N*-Hydroxy-2-(2-phenylethylsulfonamido)acetamide

Summary for 3RTS

• Entry DOI: 10.2210/pdb3rts/pdb
• Related: 3F15 3F16 3F17 3F1A 3LK8 3NX7 3RTT 3RTU
• Descriptor: Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: mmp-12, matrix metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P39900
• Total number of polymer chains: 1
• Total formula weight: 17993.82

Authors

Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Mori, M.,Nativi, C. (deposition date: 2011-05-04, release date: 2012-07-04, Last modification date: 2023-09-13)

• Primary citation: Mordini, A.,Mori, M.,Massaro, A.,Calderone, V.,Fragai, M.,Luchinat, C.; Contribution of ligand free energy of solvation to design new potent MMPs inhibitors.; J.Med.Chem., 2012

Experimental method

X-RAY DIFFRACTION (1.81 Å)