3R1G

Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody

Summary for 3R1G

• Entry DOI: 10.2210/pdb3r1g/pdb
• Descriptor: Beta-secretase 1, FAB of YW412.8.31 antibody heavy chain, FAB of YW412.8.31 antibody light chain, ... (4 entities in total)
• Functional Keywords: aspartal protease, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 3
• Total formula weight: 91285.18

Authors

Wang, W.,Rouge, L.,Wu, P.,Chiu, C.,Chen, Y.,Wu, Y.,Watts, R.J. (deposition date: 2011-03-10, release date: 2011-06-08, Last modification date: 2011-07-13)

• Primary citation: Atwal, J.K.,Chen, Y.,Chiu, C.,Mortensen, D.L.,Meilandt, W.J.,Liu, Y.,Heise, C.E.,Hoyte, K.,Luk, W.,Lu, Y.,Peng, K.,Wu, P.,Rouge, L.,Zhang, Y.,Lazarus, R.A.,Scearce-Levie, K.,Wang, W.,Wu, Y.,Tessier-Lavigne, M.,Watts, R.J.; A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo.; Sci Transl Med, 3:84ra43-84ra43, 2011; PubMed: 21613622; DOI: 10.1126/scitranslmed.3002254

Experimental method

X-RAY DIFFRACTION (2.8 Å)