3PK1

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Summary for 3PK1

Entry DOI	10.2210/pdb3pk1/pdb
Related	3PL7
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, Apoptosis regulator BAX, CADMIUM ION, ... (4 entities in total)
Functional Keywords	bcl-2 family fold, regulation of apoptosis, bax, mitochondria, apoptosis-apoptosis regulator complex, apoptosis/apoptosis regulator
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass membrane protein (Potential): Q07820 Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812
Total number of polymer chains	4
Total formula weight	52254.30
Authors	Czabotar, P.E.,Colman, P.M. (deposition date: 2010-11-11, release date: 2010-12-29, Last modification date: 2023-11-01)
Primary citation	Czabotar, P.E.,Lee, E.F.,Thompson, G.V.,Wardak, A.Z.,Fairlie, W.D.,Colman, P.M. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis J.Biol.Chem., 286:7123-7131, 2011 Cited by PubMed: 21199865 DOI: 10.1074/jbc.M110.161281 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.486 Å)

Structure validation