3PK1

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Induced myeloid leukemia cell differentiation protein Mcl-1	polymer	189	21278.1	2	UniProt (Q07820) Pfam (PF00452)	Homo sapiens (human)	Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT
2	B, D (B, D)	Apoptosis regulator BAX	polymer	34	3837.4	2	UniProt (Q07812)	Homo sapiens	Bcl-2-like protein 4, Bcl2-L-4
3	E, F, G, H, I... (A, B, C, D)	CADMIUM ION	non-polymer		112.4	18	Chemie (CD)
4	W, X, Y, Z (A, B, C, D)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, C: 174 - 326 (UniProt: Q07820)

PDB	External Database	Details
Gly 138	-	expression tag
Ser 139	-	expression tag
Gly 140	-	expression tag
Met 141	-	expression tag
Lys 142	-	expression tag
Glu 143	-	expression tag
Thr 144	-	expression tag
Ala 145	-	expression tag
Ala 146	-	expression tag
Ala 147	-	expression tag
Lys 148	-	expression tag
Phe 149	-	expression tag
Glu 150	-	expression tag
Arg 151	-	expression tag
Gln 152	-	expression tag
His 153	-	expression tag
Met 154	-	expression tag
Asp 155	-	expression tag
Ser 156	-	expression tag
Pro 157	-	expression tag
Asp 158	-	expression tag
Leu 159	-	expression tag
Gly 160	-	expression tag
Thr 161	-	expression tag
Asp 162	-	expression tag
Asp 163	-	expression tag
Asp 164	-	expression tag
Asp 165	-	expression tag
Lys 166	-	expression tag
Ala 167	-	expression tag
Met 168	-	expression tag
Ala 169	-	expression tag
Asp 170	-	expression tag
Ile 171	-	expression tag
Gly 172	-	expression tag
Ser 173	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	50230.9
Non-Polymers*	Number of molecules	18
	Total formula weight	2023.4
All*	Total formula weight	52254.3

*Water molecules are not included.