3PK1

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 1

Chain	Residue
A	GLU225
C	HOH21
C	HIS277
C	HOH327

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 2

Chain	Residue
A	HIS277
C	HOH25
C	GLU225

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 5

Chain	Residue
B	GLU69
C	ASP304
A	HOH23
A	HIS224

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 12

Chain	Residue
A	CD14
A	CYS286

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 13

Chain	Residue
A	CYS286
A	GLU288

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 14

Chain	Residue
A	CD12
A	GLU240
A	CYS286

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 17

Chain	Residue
A	GLU240
A	ASP241

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 18

Chain	Residue
A	GLU180
C	GLU284

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD B 7

Chain	Residue
B	CD8
B	CYS62

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD B 8

Chain	Residue
B	CD7
B	HOH18
B	CYS62

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 3

Chain	Residue
A	ASP304
C	HOH22
C	HIS224
D	GLU69

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 4

Chain	Residue
C	HOH34
C	HIS252

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 10

Chain	Residue
C	CD11
C	CD15

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 11

Chain	Residue
C	CD10
C	CYS286

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 15

Chain	Residue
C	CD10
C	GLU240

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD C 16

Chain	Residue
C	GLU240
C	ASP241

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD D 6

Chain	Residue
D	CYS62

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD D 9

Chain	Residue
D	CYS62

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA

Chain	Residue	Details
A	VAL253-ALA272

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV

Chain	Residue	Details
A	TRP305-VAL316

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN

Chain	Residue	Details
A	ALA209-ASN223
B	LEU59-ASN73

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Motif: {"description":"BH3","evidences":[{"source":"PubMed","id":"8521816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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