3PFP
Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Summary for 3PFP
Entry DOI | 10.2210/pdb3pfp/pdb |
Related | 2B7O 3KGF 3NUD 3NUE 3NV8 |
Descriptor | Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, (2S)-2,7-bis(phosphonooxy)heptanoic acid, ... (7 entities in total) |
Functional Keywords | shikimate pathway, mycobacterium tuberculosis, dah7p synthase, aromatic biosynthesis, tim barrel, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 103186.75 |
Authors | Reichau, S.,Jiao, W.,Walker, S.R.,Hutton, R.D.,Parker, E.J.,Baker, E.N. (deposition date: 2010-10-28, release date: 2011-03-16, Last modification date: 2023-11-01) |
Primary citation | Reichau, S.,Jiao, W.,Walker, S.R.,Hutton, R.D.,Baker, E.N.,Parker, E.J. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design J.Biol.Chem., 286:16197-16207, 2011 Cited by PubMed: 21454647DOI: 10.1074/jbc.M110.211649 PDB entries with the same primary citation |
Experimental method |
Structure validation
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