3P4W

Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC

Summary for 3P4W

• Entry DOI: 10.2210/pdb3p4w/pdb
• Related: 3P50
• Descriptor: Glr4197 protein, DODECYL-BETA-D-MALTOSIDE, (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, ... (5 entities in total)
• Functional Keywords: transmembrane helices, ligand-gated ion channel, membrane protein, transport protein
• Biological source: Gloeobacter violaceus
• Cellular location: Cell inner membrane ; Multi- pass membrane protein : Q7NDN8
• Total number of polymer chains: 5
• Total formula weight: 191876.24

Authors

Nury, H.,Van Renterghem, C.,Weng, Y.,Tran, A.,Baaden, M.,Dufresne, V.,Changeux, J.P.,Sonner, J.M.,Delarue, M.,Corringer, P.J. (deposition date: 2010-10-07, release date: 2011-01-19, Last modification date: 2023-11-01)

• Primary citation: Nury, H.,Van Renterghem, C.,Weng, Y.,Tran, A.,Baaden, M.,Dufresne, V.,Changeux, J.P.,Sonner, J.M.,Delarue, M.,Corringer, P.J.; X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel; Nature, 469:428-431, 2011; PubMed: 21248852; DOI: 10.1038/nature09647

Experimental method

X-RAY DIFFRACTION (3.2 Å)