Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3P4W

Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT A 501

Chain	Residue
A	ALA237
A	ILE240
A	LMT502

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT A 502

Chain	Residue
A	LMT501
B	LMT501
C	LMT501
E	LMT501

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DSF A 319

Chain	Residue
A	TYR197
A	ILE201
A	ILE202
A	VAL242
A	THR255
A	ILE258
A	TYR119
A	PRO120

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC A 320

Chain	Residue
A	ARG118
A	PHE121
A	TYR194
A	ILE202
A	TYR254
A	ASN307
A	PHE315

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT B 501

Chain	Residue
A	ALA237
A	LMT502
B	ILE233
B	ALA237
B	ILE240

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DSF B 319

Chain	Residue
B	TYR119
B	PRO120
B	ILE201
B	THR255
B	ILE258

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC B 320

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	ILE202
B	TYR254
B	ASN307
B	PHE315

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT C 501

Chain	Residue
A	LMT502
B	ALA237
C	ALA237
C	ILE240
D	THR244

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT C 319

Chain	Residue
C	ALA237
D	ILE233
D	ALA237
D	ILE240

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DSF C 320

Chain	Residue
C	TYR119
C	PRO120
C	TYR197
C	ILE201
C	ILE202
C	VAL242
C	THR255
C	ILE258

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC C 321

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	ILE202
C	TYR254
C	ASN307
C	PHE315

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DSF D 319

Chain	Residue
D	PRO120
D	TYR197
D	ILE201
D	ILE202
D	VAL242
D	THR255
D	ILE258
D	ILE259

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC D 320

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	ILE202
D	TYR254
D	ASN307
D	PHE315

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT E 501

Chain	Residue
A	LMT502
E	ALA237
E	ILE240

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DSF E 319

Chain	Residue
E	PRO120
E	ILE201
E	ILE202
E	VAL242
E	TYR254
E	THR255
E	ILE258

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PLC E 320

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	ILE202
E	TYR254
E	ASN307
E	PHE315

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)