3OP5
Human vaccinia-related kinase 1
Summary for 3OP5
Entry DOI | 10.2210/pdb3op5/pdb |
Descriptor | Serine/threonine-protein kinase VRK1, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | adenosine triphosphate, amino acid sequence, binding sites, catalytic domain, models, molecular, molecular sequence data, phosphotransferases, protein conformation, protein folding, surface entropy reduction, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 166372.52 |
Authors | Allerston, C.K.,Uttarkar, S.,Savitsky, P.,Elkins, J.M.,Filippakopoulos, P.,Krojer, T.,Rellos, P.,Fedorov, O.,Eswaran, J.,Brenner, B.,Keates, T.,Das, S.,King, O.,Chalk, R.,Berridge, G.,von Delft, F.,Gileadi, O.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-31, release date: 2010-09-22, Last modification date: 2023-09-06) |
Primary citation | Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7:7501-7501, 2017 Cited by PubMed: 28790404DOI: 10.1038/s41598-017-07755-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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