3O62

Nucleosome core particle modified with a cisplatin 1,3-cis-{Pt(NH3)2}2+-d(GpTpG) intrastrand cross-link

Summary for 3O62

• Entry DOI: 10.2210/pdb3o62/pdb
• Descriptor: Histone H3.2, Histone H4, Histone H2A type 1, ... (7 entities in total)
• Functional Keywords: nucleosome, cisplatin, structural protein-dna complex, structural protein/dna
• Biological source: Xenopus laevis (African clawed frog); More
• Cellular location: Nucleus: P84233 P62799 P06897 P02281
• Total number of polymer chains: 10
• Total formula weight: 198407.88

Authors

Lippard, S.J.,Todd, R.C. (deposition date: 2010-07-28, release date: 2011-01-05, Last modification date: 2024-02-21)

• Primary citation: Todd, R.C.,Lippard, S.J.; Consequences of Cisplatin binding on nucleosome structure and dynamics.; Chem.Biol., 17:1334-1343, 2010; PubMed: 21168769; DOI: 10.1016/j.chembiol.2010.10.018

Experimental method

X-RAY DIFFRACTION (3.216 Å)