3NWX
X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor
Summary for 3NWX
Entry DOI | 10.2210/pdb3nwx/pdb |
Related | 3FSM 3HAU 3HDK 3HLO 3IAW 3NWQ 3NXE 3NXN 3NYG |
Related PRD ID | PRD_001037 |
Descriptor | protease, SULFATE ION, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, ... (4 entities in total) |
Functional Keywords | beta-barrel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Total number of polymer chains | 2 |
Total formula weight | 22804.52 |
Authors | Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2010-07-12, release date: 2011-11-02, Last modification date: 2019-07-31) |
Primary citation | Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011 Cited by PubMed: 22158985DOI: 10.1073/pnas.1111202108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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