3NAN

SR Ca(2+)-ATPase in the HnE2 state complexed with a Thapsigargin derivative Boc-(phi)Tg

Summary for 3NAN

Entry DOI	10.2210/pdb3nan/pdb
Related	2BY4 2C8K 3NAL 3NAM
Descriptor	SERCA1a, POTASSIUM ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	serca, p-type atpase, ca2+-atpase, thapsigargin, prostate cancer, calcium transport, endoplasmic reticulum, hydrolase, ion transport, sarcoplasmic reticulum, transmembrane, transport
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	111344.17
Authors	Winther, A.M.L.,Sonntag, Y.,Olesen, C.,Moller, J.V.,Nissen, P. (deposition date: 2010-06-02, release date: 2010-06-30, Last modification date: 2023-11-01)
Primary citation	Winther, A.M.L.,Liu, H.,Sonntag, Y.,Olesen, C.,le Maire, M.,Soehoel, H.,Olsen, C.E.,Christensen, S.B.,Nissen, P.,Moller, J.V. Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs J.Biol.Chem., 285:28883-28892, 2010 Cited by PubMed: 20551329 DOI: 10.1074/jbc.M110.136242 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation