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2BY4

SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT.

Summary for 2BY4
Entry DOI10.2210/pdb2by4/pdb
Related1FQU 1IWO 1KJU 1SU4 1T5S 1T5T 1VFP 1WPE 1WPG 1XP5 2AGV 2C88 2C8K 2C8L 2C9M
DescriptorSARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1, (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordsserca, p-type atpase, ca2+-atpase, thapsigargin, prostate cancer, atp-binding, calcium, calcium transport, endoplasmic reticulum, hydrolase, ion transport, magnesium, metal-binding, multigene family, nucleotide-binding, phosphorylation, sarcoplasmic reticulum, transmembrane, transport
Biological sourceORYCTOLAGUS CUNICULUS (RABBIT)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein: P04191
Total number of polymer chains1
Total formula weight111057.48
Authors
Jensen, A.L.,Moller, J.V.,Soehoel, H.,Denmeade, S.R.,Isaacs, J.T.,Olsen, C.E.,Christensen, S.B.,Nissen, P. (deposition date: 2005-07-28, release date: 2006-04-07, Last modification date: 2023-12-13)
Primary citationSoehoel, H.,Jensen, A.L.,Moller, J.V.,Nissen, P.,Denmeade, S.R.,Isaacs, J.T.,Olsen, C.E.,Christensen, S.B.
Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells
Bioorg.Med.Chem., 14:2810-, 2006
Cited by
PubMed: 16412648
DOI: 10.1016/J.BMC.2005.12.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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