3MHK
Human tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol
Summary for 3MHK
Entry DOI | 10.2210/pdb3mhk/pdb |
Related | 3KR7 3KR8 3MHJ |
Descriptor | Tankyrase-2, ZINC ION, 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ... (5 entities in total) |
Functional Keywords | catalytic fragment, parp, structural genomics, structural genomics consortium, sgc, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, golgi apparatus, membrane, mrna transport, nad, nucleus, phosphorylation, protein transport, telomere, transferase, translocation, transport, wnt-signalling |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 1 |
Total formula weight | 26070.86 |
Authors | Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kotenyova, T.,Markova, N.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-08, release date: 2010-05-05, Last modification date: 2023-11-01) |
Primary citation | Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30:283-288, 2012 Cited by PubMed: 22343925DOI: 10.1038/nbt.2121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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