3MCV
Structure of PTR1 from Trypanosoma brucei in ternary complex with 2,4-diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+
Summary for 3MCV
Entry DOI | 10.2210/pdb3mcv/pdb |
Related | 2x9g 2x9n 2x9v |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total) |
Functional Keywords | pteridine reductase, antifolate, oxidoreductase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 127210.58 |
Authors | Tulloch, L.B.,Hunter, W.N. (deposition date: 2010-03-29, release date: 2010-06-02, Last modification date: 2024-02-21) |
Primary citation | Dawson, A.,Tulloch, L.B.,Barrack, K.L.,Hunter, W.N. High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target. Acta Crystallogr.,Sect.D, 66:1334-1340, 2010 Cited by PubMed: 21123874DOI: 10.1107/S0907444910040886 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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