3LZF

Crystal Structure of Fab 2D1 in Complex with the 1918 Influenza Virus Hemagglutinin

Summary for 3LZF

• Entry DOI: 10.2210/pdb3lzf/pdb
• Related: 3LZG
• Descriptor: Hemagglutinin, HA1 Subunit, Hemagglutinin, HA2 Subunit, 2D1 Fab, Heavy Chain, ... (7 entities in total)
• Functional Keywords: hemagglutinin, fab, neutralizing antibodies, antibody, pandemic flu, swine flu, envelope protein, fusion protein, glycoprotein, antigen, virion, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus (Influenza A virus); More
• Cellular location: Virion membrane; Single-pass type I membrane protein (Potential): Q9WFX3 Q9WFX3
• Total number of polymer chains: 4
• Total formula weight: 106177.88

Authors

Ekiert, D.C.,Wilson, I.A. (deposition date: 2010-03-01, release date: 2010-04-07, Last modification date: 2020-07-29)

Primary citation

Xu, R.,Ekiert, D.C.,Krause, J.C.,Hai, R.,Crowe, J.E.,Wilson, I.A.
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.
Science, 328:357-360, 2010

PubMed Abstract: The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

PubMed: 20339031
DOI: 10.1126/science.1186430

Experimental method

X-RAY DIFFRACTION (2.8 Å)