3KWW

Crystal structure of the 'restriction triad' mutant of HLA B*3508, beta-2-microglobulin and EBV peptide

Summary for 3KWW

• Entry DOI: 10.2210/pdb3kww/pdb
• Related: 3KXF
• Descriptor: HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, peptide from Trans-activator protein BZLF1, ... (7 entities in total)
• Functional Keywords: mhc-peptide, hla, disulfide bond, immune response, membrane, mhc i, polymorphism, immunoglobulin domain, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P30685; Secreted . Note=(Microbial infection) In the presence of M: P61769; Host nucleus : P03206
• Total number of polymer chains: 3
• Total formula weight: 46376.34

Authors

Archbold, J.K.,Tynan, F.E.,Gras, S.,Rossjohn, J. (deposition date: 2009-12-01, release date: 2010-06-09, Last modification date: 2023-11-01)

• Primary citation: Burrows, S.R.,Chen, Z.,Archbold, J.K.,Tynan, F.E.,Beddoe, T.,Kjer-Nielsen, L.,Miles, J.J.,Khanna, R.,Moss, D.J.,Liu, Y.C.,Gras, S.,Kostenko, L.,Brennan, R.M.,Clements, C.S.,Brooks, A.G.,Purcell, A.W.,McCluskey, J.,Rossjohn, J.; Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability; Proc.Natl.Acad.Sci.USA, 2010; PubMed: 20483993; DOI: 10.1073/pnas.1004926107

Experimental method

X-RAY DIFFRACTION (2.18 Å)