3KK2

HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site

Summary for 3KK2

• Entry DOI: 10.2210/pdb3kk2/pdb
• Related: 3kjv 3kk1 3kk3
• Descriptor: Reverse transcriptase p66 subunit, Reverse transcriptase p51 subunit, 5'-D(*AP*CP*A*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DOC))-3', ... (8 entities in total)
• Functional Keywords: hiv, reverse transcriptase, protein-dna complex, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 4
• Total formula weight: 132881.80

Authors

Lansdon, E.B. (deposition date: 2009-11-04, release date: 2010-03-23, Last modification date: 2023-09-06)

• Primary citation: Lansdon, E.B.,Samuel, D.,Lagpacan, L.,Brendza, K.M.,White, K.L.,Hung, M.,Liu, X.,Boojamra, C.G.,Mackman, R.L.,Cihlar, T.,Ray, A.S.,McGrath, M.E.,Swaminathan, S.; Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.; J.Mol.Biol., 397:967-978, 2010; PubMed: 20156454; DOI: 10.1016/j.jmb.2010.02.019

Experimental method

X-RAY DIFFRACTION (2.9 Å)