3KK2
HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Reverse transcriptase p66 subunit | polymer | 560 | 64521.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 (HIV-1) | p66 RT |
2 | B | Reverse transcriptase p51 subunit | polymer | 452 | 52748.4 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 (HIV-1) | p51 RT |
3 | P | 5'-D(*AP*CP*A*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DOC))-3' | polymer | 21 | 6360.1 | 1 | |||
4 | T | 5'-D(*A*TP*GP*GP*TP*GP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3' | polymer | 27 | 8423.4 | 1 | |||
5 | A, P | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
6 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
7 | A | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 1 | Chemie (DTP) | |||
8 | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
PDB | External Database | Details |
---|---|---|
Cys 258 | Gln 845 | engineered mutation |
Ser 280 | Cys 867 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -11 | - | expression tag |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 132053.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 828.0 | |
All* | Total formula weight | 132881.8 |