3K2P
HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
Summary for 3K2P
Entry DOI | 10.2210/pdb3k2p/pdb |
Descriptor | Reverse Transcriptase, MANGANESE (II) ION, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, ... (4 entities in total) |
Functional Keywords | rnase h inhibitor, reverse transcriptase, aids, hiv, protein-inhibitor complex, structure-based drug design, tropolones, tropylium ion, divalent cation chelator, metal-binding, rna-binding, hydrolase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 |
Total number of polymer chains | 2 |
Total formula weight | 30490.22 |
Authors | Pauly, T.A.,Himmel, D.M.,Maegley, K.,Arnold, E. (deposition date: 2009-09-30, release date: 2010-02-09, Last modification date: 2024-02-21) |
Primary citation | Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Bauman, J.D.,Das, K.,Dharia, C.,Clark, A.D.,Ryan, K.,Hickey, M.J.,Love, R.A.,Hughes, S.H.,Bergqvist, S.,Arnold, E. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure, 17:1625-1635, 2009 Cited by PubMed: 20004166DOI: 10.1016/j.str.2009.09.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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