3K15
Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus
Summary for 3K15
Entry DOI | 10.2210/pdb3k15/pdb |
Related | 3K05 3K0H 3K0K 3K15 |
Descriptor | Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ... (5 entities in total) |
Functional Keywords | brca1, brct domain, dna damage response, phospho peptide interactions, bach1, alternative initiation, cell cycle, disease mutation, dna damage, dna repair, dna-binding, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, nucleus, phosphoprotein, tumor suppressor, ubl conjugation pathway, zinc-finger, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 |
Total number of polymer chains | 2 |
Total formula weight | 25271.07 |
Authors | Campbell, S.J.,Edwards, R.A.,Glover, J.N. (deposition date: 2009-09-25, release date: 2010-03-02, Last modification date: 2021-10-13) |
Primary citation | Campbell, S.J.,Edwards, R.A.,Glover, J.N. Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1 Structure, 18:167-176, 2010 Cited by PubMed: 20159462DOI: 10.1016/j.str.2009.12.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report