3K0K
Crystal Structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus.
Summary for 3K0K
Entry DOI | 10.2210/pdb3k0k/pdb |
Related | 3K05 3K0H |
Descriptor | Breast cancer type 1 susceptibility protein, phospho peptide pSPTF-COOH, NICKEL (II) ION, ... (5 entities in total) |
Functional Keywords | brca1, brct domain, dna damage response, phospho peptide interactions, abraxas, alternative initiation, cell cycle, disease mutation, dna damage, dna repair, dna-binding, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, nucleus, phosphoprotein, tumor suppressor, ubl conjugation pathway, zinc-finger, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 |
Total number of polymer chains | 2 |
Total formula weight | 25287.04 |
Authors | Campbell, S.J.,Edwards, R.A.,Glover, J.N. (deposition date: 2009-09-24, release date: 2010-03-02, Last modification date: 2017-11-01) |
Primary citation | Campbell, S.J.,Edwards, R.A.,Glover, J.N. Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1 Structure, 18:167-176, 2010 Cited by PubMed: 20159462DOI: 10.1016/j.str.2009.12.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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