3JVW

HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323

Summary for 3JVW

Entry DOI	10.2210/pdb3jvw/pdb
Related	2IEN 3JVY 3JW2
Descriptor	Gag-Pol polyprotein, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (3 entities in total)
Functional Keywords	hiv-1 protease, mutant g86a, symmetric inhibitor, dmp323, aids, aspartyl protease, hydrolase
Biological source	Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22076.09
Authors	Tie, Y.,Weber, I.T. (deposition date: 2009-09-17, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Ishima, R.,Gong, Q.,Tie, Y.,Weber, I.T.,Louis, J.M. Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease Proteins, 78:1015-1025, 2009 Cited by PubMed: 19899162 DOI: 10.1002/prot.22625 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation