3JVW
HIV-1 Protease Mutant G86A with symmetric inhibitor DMP323
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Gag-Pol polyprotein | polymer | 99 | 10754.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) | Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, Retropepsin, PR, Reverse transcriptase/ribonuclease H, p66 RT, p51 RT, p15, Integrase, IN |
| 2 | C (A) | [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE | non-polymer | 566.7 | 1 | Chemie (DMP) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 86 | Gly 586 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21509.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 566.7 | |
| All* | Total formula weight | 22076.1 |
