3IWM
The octameric SARS-CoV main protease
Summary for 3IWM
Entry DOI | 10.2210/pdb3iwm/pdb |
Related PRD ID | PRD_002214 |
Descriptor | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (2 entities in total) |
Functional Keywords | sars-cov, main protease, octamer, active conformation, hydrolase |
Biological source | SARS coronavirus (SARS-CoV) More |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 8 |
Total formula weight | 138229.71 |
Authors | |
Primary citation | Zhang, S.,Zhong, N.,Xue, F.,Kang, X.,Ren, X.,Chen, J.,Jin, C.,Lou, Z.,Xia, B. Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease Protein Cell, 1:371-383, 2010 Cited by PubMed: 21203949DOI: 10.1007/s13238-010-0044-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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