Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019082 | biological_process | viral protein processing |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019082 | biological_process | viral protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN H OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| A | THR25 |
| A | HIS163 |
| A | HIS164 |
| A | MET165 |
| A | GLU166 |
| A | PRO168 |
| A | ASP187 |
| A | ARG188 |
| A | GLN189 |
| A | THR190 |
| A | ALA191 |
| A | THR26 |
| A | LEU27 |
| A | HIS41 |
| A | PHE140 |
| A | LEU141 |
| A | ASN142 |
| A | GLY143 |
| A | CYS145 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN F OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| B | THR25 |
| B | HIS41 |
| B | PHE140 |
| B | ASN142 |
| B | GLY143 |
| B | CYS145 |
| B | HIS163 |
| B | HIS164 |
| B | MET165 |
| B | GLU166 |
| B | PRO168 |
| B | GLN189 |
| B | THR190 |
| B | GLN192 |
| C | THR24 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN G OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| B | THR24 |
| C | LEU27 |
| C | HIS41 |
| C | MET49 |
| C | PHE140 |
| C | ASN142 |
| C | GLY143 |
| C | CYS145 |
| C | HIS163 |
| C | HIS164 |
| C | MET165 |
| C | GLU166 |
| C | LEU167 |
| C | PRO168 |
| C | ARG188 |
| C | GLN189 |
| C | THR190 |
| C | ALA191 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN E OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| D | THR26 |
| D | HIS41 |
| D | PHE140 |
| D | LEU141 |
| D | ASN142 |
| D | GLY143 |
| D | CYS145 |
| D | HIS163 |
| D | HIS164 |
| D | MET165 |
| D | GLU166 |
| D | LEU167 |
| D | PRO168 |
| D | ASP187 |
| D | ARG188 |
| D | GLN189 |
| D | THR190 |
| D | ALA191 |
| D | GLN192 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| A | HIS41 | proton acceptor, proton donor |
| A | GLY143 | electrostatic stabiliser |
| A | CYS145 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| B | HIS41 | proton acceptor, proton donor |
| B | GLY143 | electrostatic stabiliser |
| B | CYS145 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| C | HIS41 | proton acceptor, proton donor |
| C | GLY143 | electrostatic stabiliser |
| C | CYS145 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| D | HIS41 | proton acceptor, proton donor |
| D | GLY143 | electrostatic stabiliser |
| D | CYS145 | electrostatic stabiliser |
