3IU3
Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain
Summary for 3IU3
Entry DOI | 10.2210/pdb3iu3/pdb |
Descriptor | Heavy chain of Fab fragment of Basiliximab, Light chain of Fab fragment of Basiliximab, Interleukin-2 receptor alpha chain, ... (4 entities in total) |
Functional Keywords | il-2ra, cd25, basiliximab, simulect, therapeutic antibody, disulfide bond, glycoprotein, membrane, receptor, sushi, transmembrane, immune system |
Biological source | Mus musculus, Homo sapiens (mouse, human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01589 |
Total number of polymer chains | 9 |
Total formula weight | 216006.16 |
Authors | |
Primary citation | Du, J.,Yang, H.,Zhang, D.,Wang, J.,Guo, H.,Peng, B.,Guo, Y.,Ding, J. Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab J.Immunol., 184:1361-1368, 2010 Cited by PubMed: 20032294DOI: 10.4049/jimmunol.0903178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report