3IQU
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)
Summary for 3IQU
Entry DOI | 10.2210/pdb3iqu/pdb |
Related | 3CU8 3IQJ 3IQV |
Descriptor | 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | signal transuction, nucleus, phosphoprotein, secreted, protein binding, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P31947 P04049 |
Total number of polymer chains | 2 |
Total formula weight | 27426.96 |
Authors | Ottmann, C.,Weyand, M. (deposition date: 2009-08-21, release date: 2010-09-01, Last modification date: 2023-11-22) |
Primary citation | Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30:4698-4711, 2010 Cited by PubMed: 20679480DOI: 10.1128/MCB.01636-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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