3IPH
Crystal structure of p38 in complex with a biphenylamide inhibitor
Summary for 3IPH
Entry DOI | 10.2210/pdb3iph/pdb |
Related | 2ZAZ 2ZB0 2ZB1 3D7Z 3D83 |
Descriptor | Mitogen-activated protein kinase 14, 6-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | p38, serine/threonine protein kinase, map kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42373.25 |
Authors | Somers, D.O. (deposition date: 2009-08-17, release date: 2009-11-24, Last modification date: 2023-11-22) |
Primary citation | Aston, N.M.,Bamborough, P.,Buckton, J.B.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Patel, V.K.,Smee, P.A.,Somers, D.O.,Vitulli, G.,Walker, A.L. p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J.Med.Chem., 52:6257-6269, 2009 Cited by PubMed: 19772287DOI: 10.1021/jm9004779 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report