3IC0

Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298

Summary for 3IC0

• Entry DOI: 10.2210/pdb3ic0/pdb
• Related: 3IC2
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, OXYGEN MOLECULE, ... (7 entities in total)
• Functional Keywords: heme protein, hemoglobin, antisickling agents, acetylation, disease mutation, glycation, glycoprotein, heme, iron, metal-binding, oxygen transport, phosphoprotein, polymorphism, transport, hypotensive agent, pyruvate, s-nitrosylation, vasoactive
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 65784.27

Authors

Safo, M.K.,Musayev, F.N.,Gandhi, A.K.,Jorge, P. (deposition date: 2009-07-17, release date: 2009-07-28, Last modification date: 2023-09-06)

• Primary citation: Osheiza, A.,Mohini, G.,Ijoema, N.,Amit, K.G.,Faik, N.M.,Richmond, D.-D.,Toshio, A.,Martin, K.S.; Structural and in Vitro Chracterization of Pridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)