3IC2
Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266
Summary for 3IC2
Entry DOI | 10.2210/pdb3ic2/pdb |
Related | 3IC0 |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, OXYGEN MOLECULE, ... (7 entities in total) |
Functional Keywords | heme protein, hemoglobin, antisickling agents, acetylation, disease mutation, glycation, glycoprotein, heme, iron, metal-binding, oxygen transport, phosphoprotein, polymorphism, transport, hypotensive agent, pyruvate, s-nitrosylation, vasoactive |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 65229.66 |
Authors | Safo, M.K.,Musayev, F.N.,Gandhi, A.K.,Jorge, P. (deposition date: 2009-07-17, release date: 2009-07-28, Last modification date: 2023-09-06) |
Primary citation | Osheiza, A.,Mohini, G.,Ijoema, N.,Amit, K.G.,Faik, N.M.,Richmond, D.-D.,Toshio, A.,Martin, K.S. Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes: Highly Potent Antisickling Agents To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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