3I6K

Newly identified epitope from SARS-CoV membrane protein complexed with HLA-A*0201

Summary for 3I6K

• Entry DOI: 10.2210/pdb3i6k/pdb
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Membrane glycoprotein peptide, ... (4 entities in total)
• Functional Keywords: hla-a2, sars-cov, membrane glycoprotein, disulfide bond, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, envelope protein, golgi apparatus, viral matrix protein, virion, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• Total number of polymer chains: 6
• Total formula weight: 89481.61

Authors

Liu, J.,Sun, Y.,Qi, J.,Chu, F.,Wu, H.,Gao, F.,Li, T.,Yan, J.,Gao, G.F. (deposition date: 2009-07-07, release date: 2010-06-16, Last modification date: 2024-10-30)

Primary citation

Liu, J.,Sun, Y.,Qi, J.,Chu, F.,Wu, H.,Gao, F.,Li, T.,Yan, J.,Gao, G.F.
The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes
J Infect Dis, 202:1171-1180, 2010

PubMed Abstract: Severe acute respiratory syndrome coronavirus (SARS-CoV), which emerged with highly contagious and life-threatening characteristics in 2002, remains a potential risk for future outbreaks. Membrane (M) and envelope (E) proteins are major structural proteins of the SARS-CoV. The M protein has been determined as a protective antigen in humoral responses. However, its potential roles in stimulating cellular immunity remain elusive.

PubMed: 20831383
DOI: 10.1086/656315

Experimental method

X-RAY DIFFRACTION (2.8 Å)