3HZG
Crystal structure of mycobacterium tuberculosis thymidylate synthase X bound with FAD
Summary for 3HZG
Entry DOI | 10.2210/pdb3hzg/pdb |
Related | 3GWC |
Descriptor | Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | thyx, fad, thymidylate synthase, flavoprotein, methyltransferase, nucleotide biosynthesis, transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 119070.94 |
Authors | Staker, B.L.,Rathod, P.,Hunter, J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-06-23, release date: 2009-07-07, Last modification date: 2023-09-06) |
Primary citation | Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95:142-148, 2015 Cited by PubMed: 25613812DOI: 10.1016/j.tube.2014.12.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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