3HV5

Human p38 MAP Kinase in Complex with RL24

Summary for 3HV5

Entry DOI	10.2210/pdb3hv5/pdb
Related	3GCP 3GCQ 3GCS 3GCU 3GCV 3HV3 3HV4 3HV6 3HV7
Descriptor	Mitogen-activated protein kinase 14, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea, octyl beta-D-glucopyranoside, ... (5 entities in total)
Functional Keywords	dfg-out, type ii, rl24, quinoline-pyrazolourea, hybrid, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	84681.65
Authors	Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2009-06-15, release date: 2009-11-17, Last modification date: 2023-09-06)
Primary citation	Kluter, S.,Grutter, C.,Naqvi, T.,Rabiller, M.,Simard, J.R.,Pawar, V.,Getlik, M.,Rauh, D. Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53:357-367, 2010 Cited by PubMed: 19928858 DOI: 10.1021/jm901297e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation