3HUS

Crystal structure of recombinant gamma N308K fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide

Summary for 3HUS

• Entry DOI: 10.2210/pdb3hus/pdb
• Related: 1LT9 1LTJ
• Descriptor: Fibrinogen alpha chain, Fibrinogen beta chain, Fibrinogen gamma chain, ... (7 entities in total)
• Functional Keywords: fibrinogen fragment d, amyloid, amyloidosis, blood coagulation, disease mutation, disulfide bond, glycoprotein, isopeptide bond, phosphoprotein, secreted, pyrrolidone carboxylic acid, sulfation, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 160847.99

Authors

Lord, S.T.,Bowley, S.R.,Okumura, N. (deposition date: 2009-06-15, release date: 2009-08-18, Last modification date: 2023-09-06)

• Primary citation: Bowley, S.R.,Okumura, N.,Lord, S.T.; Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and "A:a" interactions.; Biochemistry, 48:8656-8663, 2009; PubMed: 19650644; DOI: 10.1021/bi900239b

Experimental method

X-RAY DIFFRACTION (3.04 Å)