3HM1
Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)
Summary for 3HM1
Entry DOI | 10.2210/pdb3hm1/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (4 entities in total) |
Functional Keywords | estrogen receptor, lbd, grip peptide, estrone, alternative splicing, dna-binding, glycoprotein, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, steroid-binding, transcription, transcription regulation, zinc, zinc-finger, activator, hormone, nuclear receptor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 Nucleus: Q9WUI9 |
Total number of polymer chains | 4 |
Total formula weight | 62043.49 |
Authors | Rajan, S.S.,Kim, Y.,Vanek, K.,Liwanag, M.,Joachimiak, A.,Greene, G.L. (deposition date: 2009-05-28, release date: 2010-06-02, Last modification date: 2023-09-06) |
Primary citation | Rajan, S.S.,Kim, Y.,Vanek, K.,Joachimiak, A.,Greene, G.L. Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one) To be Published, |
Experimental method |
Structure validation
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