3HI1

Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105

Summary for 3HI1

• Entry DOI: 10.2210/pdb3hi1/pdb
• Descriptor: Glycoprotein 120, F105 Light Chain, F105 Heavy Chain, ... (5 entities in total)
• Functional Keywords: hiv, gp120, cd4 binding site antibody, f105, immune evasion, aids, apoptosis, cell membrane, cleavage on pair of basic residues, disulfide bond, envelope protein, fusion protein, glycoprotein, host-virus interaction, lipoprotein, membrane, palmitate, transmembrane, viral immunoevasion, virion, structural protein-immune system complex, structural protein/immune system
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Total number of polymer chains: 6
• Total formula weight: 172578.10

Authors

Kwon, Y.D.,Chen, L.,Zhou, T.,Wu, X.,O'Dell, S.,Cavacini, L.,Hessell, A.J.,Pancera, M.,Tang, M.,Xu, L.,Yang, Z.,Zhang, M.-Y.,Arthos, J.,Burton, D.R.,Dimitrov, D.,Nabel, G.J.,Posner, M.,Sodroski, J.,Wyatt, R.,Mascola, J.R.,Kwong, P.D. (deposition date: 2009-05-18, release date: 2009-11-17, Last modification date: 2023-09-06)

• Primary citation: Chen, L.,Do Kwon, Y.,Zhou, T.,Wu, X.,O'Dell, S.,Cavacini, L.,Hessell, A.J.,Pancera, M.,Tang, M.,Xu, L.,Yang, Z.Y.,Zhang, M.Y.,Arthos, J.,Burton, D.R.,Dimitrov, D.S.,Nabel, G.J.,Posner, M.R.,Sodroski, J.,Wyatt, R.,Mascola, J.R.,Kwong, P.D.; Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.; Science, 326:1123-1127, 2009; PubMed: 19965434; DOI: 10.1126/science.1175868

Experimental method

X-RAY DIFFRACTION (2.9 Å)