3HF8
Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe
Summary for 3HF8
Entry DOI | 10.2210/pdb3hf8/pdb |
Related | 3HF6 3HFB |
Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, ... (4 entities in total) |
Functional Keywords | tryoptophan hydroxylase type 1, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33870.24 |
Authors | Tari, L.W.,Swanson, R.V.,Hunter, M.J. (deposition date: 2009-05-11, release date: 2010-04-21, Last modification date: 2024-02-21) |
Primary citation | Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4:19-26, 2010 Cited by PubMed: 20556201DOI: 10.2174/1875397301004010019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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