3HEG

P38 in complex with Sorafenib

Summary for 3HEG

Entry DOI	10.2210/pdb3heg/pdb
Related	3HEC
Descriptor	Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total)
Functional Keywords	transferases, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q16539
Total number of polymer chains	1
Total formula weight	40370.52
Authors	Namboodiri, H.V.,Karpusas, M. (deposition date: 2009-05-08, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Namboodiri, H.V.,Bukhtiyarova, M.,Ramcharan, J.,Karpusas, M.,Lee, Y.,Springman, E.B. Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49:3611-3618, 2010 Cited by PubMed: 20337484 DOI: 10.1021/bi100070r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation