3HEC
P38 in complex with Imatinib
Summary for 3HEC
Entry DOI | 10.2210/pdb3hec/pdb |
Related | 3HEG |
Descriptor | Mitogen-activated protein kinase 14, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | transferase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40691.67 |
Authors | Namboodiri, H.V.,Karpusas, M. (deposition date: 2009-05-08, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Namboodiri, H.V.,Bukhtiyarova, M.,Ramcharan, J.,Karpusas, M.,Lee, Y.,Springman, E.B. Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49:3611-3618, 2010 Cited by PubMed: 20337484DOI: 10.1021/bi100070r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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