3HEC

P38 in complex with Imatinib

Summary for 3HEC

Entry DOI	10.2210/pdb3hec/pdb
Related	3HEG
Descriptor	Mitogen-activated protein kinase 14, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	transferase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40691.67
Authors	Namboodiri, H.V.,Karpusas, M. (deposition date: 2009-05-08, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Namboodiri, H.V.,Bukhtiyarova, M.,Ramcharan, J.,Karpusas, M.,Lee, Y.,Springman, E.B. Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49:3611-3618, 2010 Cited by PubMed: 20337484 DOI: 10.1021/bi100070r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation