3GKY
The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape
Summary for 3GKY
Entry DOI | 10.2210/pdb3gky/pdb |
Related | 1TRZ |
Descriptor | Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein folding, er stress-associated, tr transition receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted |
Biological source | Sus scrofa (pig) More |
Cellular location | Secreted: P01315 P01315 |
Total number of polymer chains | 4 |
Total formula weight | 11917.12 |
Authors | Liu, M.,Wan, Z.L.,Chu, Y.C.,Alddin, H.,Klaproth, B.,Weiss, M.A. (deposition date: 2009-03-11, release date: 2009-03-24, Last modification date: 2023-09-06) |
Primary citation | Liu, M.,Wan, Z.L.,Chu, Y.C.,Aladdin, H.,Klaproth, B.,Choquette, M.,Hua, Q.X.,Mackin, R.B.,Rao, J.S.,De Meyts, P.,Katsoyannis, P.G.,Arvan, P.,Weiss, M.A. Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284:35259-35272, 2009 Cited by PubMed: 19850922DOI: 10.1074/jbc.M109.046888 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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