3GGC
Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)hypoxanthine
Summary for 3GGC
Entry DOI | 10.2210/pdb3ggc/pdb |
Related | 1D6N 1HMP 1Z7G |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, {2-[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid (3 entities in total) |
Functional Keywords | purine salvage, phosphoribosyltransferase, acyclic nucleoside phosphonate, disease mutation, glycosyltransferase, gout, magnesium, metal-binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 2 |
Total formula weight | 49538.83 |
Authors | Guddat, L.W.,Keough, D.T.,Jersey, J. (deposition date: 2009-02-27, release date: 2009-08-18, Last modification date: 2023-11-01) |
Primary citation | Keough, D.T.,Hockova, D.,Holy, A.,Naesens, L.M.,Skinner-Adams, T.S.,Jersey, J.,Guddat, L.W. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J.Med.Chem., 52:4391-4399, 2009 Cited by PubMed: 19527031DOI: 10.1021/jm900267n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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