3G8I
Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes
Summary for 3G8I
Entry DOI | 10.2210/pdb3g8i/pdb |
Related | 3G9E |
Descriptor | Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor, transcription factor, diabetes, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: Q07869 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32670.12 |
Authors | Benz, J.,Bernardeau, A.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Maerki, H.P.,Meyer, M.,Puentener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Gsell, B.,Stihle, M.,Mohr, P. (deposition date: 2009-02-12, release date: 2009-06-02, Last modification date: 2023-11-01) |
Primary citation | Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Marki, H.P.,Meyer, M.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Mohr, P. Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. Bioorg.Med.Chem.Lett., 19:2468-2473, 2009 Cited by PubMed: 19349176DOI: 10.1016/j.bmcl.2009.03.036 PDB entries with the same primary citation |
Experimental method |
Structure validation
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