3G6J
C3b in complex with a C3b specific Fab
Summary for 3G6J
Entry DOI | 10.2210/pdb3g6j/pdb |
Related | 2I07 2ICF |
Descriptor | Complement C3 beta chain, Complement C3 alpha chain, Fab light chain, ... (5 entities in total) |
Functional Keywords | complement, c3b, fab, antibody:antigen, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01024 P01024 |
Total number of polymer chains | 8 |
Total formula weight | 445149.84 |
Authors | Wiesmann, C. (deposition date: 2009-02-06, release date: 2009-03-10, Last modification date: 2023-09-06) |
Primary citation | Katschke, K.J.,Stawicki, S.,Yin, J.,Steffek, M.,Xi, H.,Sturgeon, L.,Hass, P.E.,Loyet, K.M.,Deforge, L.,Wu, Y.,van Lookeren Campagne, M.,Wiesmann, C. Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement J.Biol.Chem., 284:10473-10479, 2009 Cited by PubMed: 19196712DOI: 10.1074/jbc.M809106200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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