3G6H
Src Thr338Ile inhibited in the DFG-Asp-Out conformation
Summary for 3G6H
Entry DOI | 10.2210/pdb3g6h/pdb |
Related | 3G6G |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | cancer, imatinib resistance, dsa compounds, kinase, dfg-asp-out, alternative splicing, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Gallus gallus (chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66109.00 |
Authors | Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J. (deposition date: 2009-02-06, release date: 2009-03-24, Last modification date: 2023-09-06) |
Primary citation | Seeliger, M.A.,Ranjitkar, P.,Kasap, C.,Shan, Y.,Shaw, D.E.,Shah, N.P.,Kuriyan, J.,Maly, D.J. Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Res., 69:2384-2392, 2009 Cited by PubMed: 19276351DOI: 10.1158/0008-5472.CAN-08-3953 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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