3G6H
Src Thr338Ile inhibited in the DFG-Asp-Out conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32738.7 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (chicken) | pp60c-src, p60-Src, c-Src |
| 2 | C (B) | N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide | non-polymer | 631.6 | 1 | Chemie (G6H) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Ile 338 | Thr 338 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65477.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 631.6 | |
| All* | Total formula weight | 66109.0 |
