3FNU

Crystal structure of KNI-10006 bound histo-aspartic protease (HAP) from Plasmodium falciparum

Summary for 3FNU

• Entry DOI: 10.2210/pdb3fnu/pdb
• Related: 3FNS 3FNT
• Related PRD ID: PRD_000575
• Descriptor: HAP protein, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (3 entities in total)
• Functional Keywords: histo-aspartic protease, hydrolase, plasmepsin, aspartic protease, kni, kni-10006, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 4
• Total formula weight: 152268.13

Authors

Bhaumik, P.,Gustchina, A.,Wlodawer, A. (deposition date: 2008-12-26, release date: 2009-05-12, Last modification date: 2017-11-01)

• Primary citation: Bhaumik, P.,Xiao, H.,Parr, C.L.,Kiso, Y.,Gustchina, A.,Yada, R.Y.,Wlodawer, A.; Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.; J.Mol.Biol., 388:520-540, 2009; PubMed: 19285084; DOI: 10.1016/j.jmb.2009.03.011

Experimental method

X-RAY DIFFRACTION (3 Å)