3FNU
Crystal structure of KNI-10006 bound histo-aspartic protease (HAP) from Plasmodium falciparum
Summary for 3FNU
Entry DOI | 10.2210/pdb3fnu/pdb |
Related | 3FNS 3FNT |
Related PRD ID | PRD_000575 |
Descriptor | HAP protein, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (3 entities in total) |
Functional Keywords | histo-aspartic protease, hydrolase, plasmepsin, aspartic protease, kni, kni-10006, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 4 |
Total formula weight | 152268.13 |
Authors | Bhaumik, P.,Gustchina, A.,Wlodawer, A. (deposition date: 2008-12-26, release date: 2009-05-12, Last modification date: 2017-11-01) |
Primary citation | Bhaumik, P.,Xiao, H.,Parr, C.L.,Kiso, Y.,Gustchina, A.,Yada, R.Y.,Wlodawer, A. Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. J.Mol.Biol., 388:520-540, 2009 Cited by PubMed: 19285084DOI: 10.1016/j.jmb.2009.03.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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